Since the discovery of circulating cell-free fetal DNA (ccffDNA) Sneak peek NIPT Early gender test Pregnancy Fetal sex Maternal blood Maternal plasma Cell-free fetal The SneakPeekĮarly Gender DNA Test can provide prenatal genetic information a month earlier than traditional noninvasive SneakPeek gender test is the earliest and most accurate method for fetal sex determination. No false positive or false negative resultsĬonclusion: SneakPeek® Early Gender Test was shown to be 100% accurate for fetal sex determination at 6 weeks Were 100%, 100%, and 100% for fetal sex identification, respectively. SneakPeek accuracy, sensitivity, and specificity Sonogram results matched the SneakPeek test results in this study. Test results at later gestational ages (7 and 8+ weeks) matched the six-week test results. Results: SneakPeek accurately determined fetal sex at six weeks for 113 subjects in this study, results for two subjects Sonography wasĪlso used to confirm SneakPeek test results for 103 pregnancies in the study. Six-week gestation samples were confirmed with the 7-week and 8-week to 10-week sample results. Test was found to be 99.9% accurate at 7-weeks’ and 8-weeks’ gestation or later, the fetal sex test results for Fetal sex was determined from the qPCR results using an algorithm that includes the QuantificationĬycle (Cq) values of the Y-target sequence and autosomal control gene. Real-time quantitative PCR was utilized to detect male fetalĭNA using a multi-copy sequence on the Y chromosome and total cell-free DNA using an autosomal control Was extracted from the maternal plasma samples. Using a commercial DNA isolation kit, circulating cell-free DNA (ccfDNA) Maternal plasma was separated from whole blood via centrifugation. Three to four milliliters (mL) of maternal blood were drawn from each participant via venipuncture at three gestational ages (i.e., 6, 7, and 8 - 10 weeks’ gestation). Pregnancy, or miscalculated gestational age at the time of the initial sample collection, 115 individuals completed After excluding participants that reported miscarriage during the study, reported twin/triplet Method: Between May and September 2021, 156 pregnant women were recruited from 12 clinics in the To enable fetal sex identification at earlier gestations and its performance characteristics were determined at 6-weeks’ The SneakPeek assay was further optimized Maternal plasma earlier than seven weeks of gestation with high accuracy. To our knowledge, no prior study has shown fetal sex identification from Background: The SneakPeek® Early Gender Test was previously shown to be 99.9% accurate in determining fetal sexĪs early as seven weeks of gestation.
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